Yeni bir ara\u015ft\u0131rmaya g\u00f6re, \u00c7in’de geli\u015ftirilen\u00a0potansiyel bir\u00a0koronavir\u00fcs a\u015f\u0131s\u0131<\/u>\u00a0, 100’den fazla ki\u015fide denemeden sonra g\u00fcvenli ve ba\u011f\u0131\u015f\u0131kl\u0131k sa\u011fland\u0131.<\/p>\n\n\n\n
Ad5-nCoV ad\u0131 verilen a\u015f\u0131, \u00c7inli CanSino Biologics \u015firketi taraf\u0131ndan geli\u015ftiriliyor ve Mart ay\u0131nda insan deneklerine giren ilk koronavir\u00fcs a\u015f\u0131lar\u0131ndan biriydi.\u00a0\u015eimdi, d\u00fcnya \u00e7ap\u0131nda geli\u015ftirilmekte olan 100’den fazla farkl\u0131 koronavir\u00fcs a\u015f\u0131s\u0131 vard\u0131r ve bunlar\u0131n en az sekiz tanesi insan denemeleri s\u00fcrecindedir.<\/p>\n\n\n\n
Ad5-nCoV, COVID’ye\u00a0neden olan vir\u00fcs SARS-CoV-2’den bir genetik materyal par\u00e7as\u0131 sa\u011flamak i\u00e7in, insan h\u00fccrelerini enfekte eden ancak hastal\u0131\u011fa neden olmayan\u00a0yayg\u0131n bir so\u011fuk vir\u00fcs\u00fcn (\u00a0adenovir\u00fcs<\/u>\u00a0olarak bilinir\u00a0)\u00a0zay\u0131flam\u0131\u015f bir versiyonunu kullan\u0131r.\u00a019.\u00a0Bu genetik materyal SARS-CoV-2’nin y\u00fczeyinde “ba\u015fak proteini” yapmak i\u00e7in talimatlar sa\u011flar.\u00a0Fikir, bir ki\u015finin\u00a0ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin<\/u>\u00a0, daha sonra maruz kalmas\u0131 durumunda koronavir\u00fcs ile sava\u015fmaya yard\u0131mc\u0131 olacak ba\u015fak proteinine kar\u015f\u0131 antikorlar olu\u015fturdu.<\/p>\n\n\n\n
22 May\u0131s Cuma g\u00fcn\u00fc\u00a0The Lancet<\/u>\u00a0dergisinde yay\u0131nlanan yeni \u00e7al\u0131\u015fmada,\u00a0ara\u015ft\u0131rmac\u0131lar Ad5-nCoV’u COVID-19’a sahip olmayan 18 ila 60 ya\u015flar\u0131 aras\u0131ndaki 108 sa\u011fl\u0131kl\u0131 insanda test ettiler.\u00a0Kat\u0131l\u0131mc\u0131lar d\u00fc\u015f\u00fck, orta veya y\u00fcksek dozda a\u015f\u0131 verildi.<\/p>\n\n\n\n
A\u015f\u0131dan iki hafta sonra, her \u00fc\u00e7 gruptaki kat\u0131l\u0131mc\u0131lar vir\u00fcse kar\u015f\u0131 bir miktar ba\u011f\u0131\u015f\u0131kl\u0131k tepkisi g\u00f6sterdi. 28 g\u00fcne kadar neredeyse t\u00fcm kat\u0131l\u0131mc\u0131lar SARS-CoV-2’ye ba\u011fl\u0131 olan (ancak mutlaka vir\u00fcse sald\u0131rmayan) antikorlar geli\u015ftirdiler ve d\u00fc\u015f\u00fck ve orta doz gruplar\u0131ndaki kat\u0131l\u0131mc\u0131lar\u0131n yakla\u015f\u0131k yar\u0131s\u0131 ve kat\u0131l\u0131mc\u0131lar\u0131n d\u00f6rtte \u00fc\u00e7\u00fc y\u00fcksek doz grubunda, vir\u00fcse h\u00fccreleri enfekte etmesini \u00f6nlemek i\u00e7in ba\u011flanan ve devre d\u0131\u015f\u0131 b\u0131rakan “n\u00f6tralize edici antikorlar” geli\u015ftirildi.<\/p>\n\n\n\n
Yayg\u0131n yan etkiler enjeksiyon b\u00f6lgesinde hafif a\u011fr\u0131, hafif ate\u015f, yorgunluk, ba\u015f a\u011fr\u0131s\u0131 ve kas a\u011fr\u0131s\u0131d\u0131r.\u00a0<\/p>\n\n\n\n
Bununla birlikte, dokuz kat\u0131l\u0131mc\u0131 (d\u00fc\u015f\u00fck doz grubunda iki, orta doz grubunda iki ve y\u00fcksek doz grubunda be\u015f) 101 Fahrenhayttan (38.5 santigrat derece) daha y\u00fcksek bir ate\u015f geli\u015ftirdi ve y\u00fcksek doz grubunda bir kat\u0131l\u0131mc\u0131 geli\u015fti. yorgunluk, nefes darl\u0131\u011f\u0131 ve kas a\u011fr\u0131s\u0131 ile birlikte y\u00fcksek ate\u015f. Ancak bu etkiler 48 saatten fazla s\u00fcrmedi.<\/p>\n\n\n\n
New York Times’a<\/u>\u00a0g\u00f6re, kat\u0131l\u0131mc\u0131lar hangi doz ald\u0131klar\u0131n\u0131n, yan etki alg\u0131lar\u0131n\u0131 etkilemi\u015f olabilece\u011finin fark\u0131ndayd\u0131\u00a0.<\/p>\n\n\n\n
Pekin, \u00c7in’deki Pekin Biyoteknoloji Enstit\u00fcs\u00fc’nden k\u0131demli yazar Wei Chen, “Bu sonu\u00e7lar \u00f6nemli bir kilometre ta\u015f\u0131n\u0131 temsil ediyor” a\u00e7\u0131klamas\u0131nda yapt\u0131\u011f\u0131 a\u00e7\u0131klamada, “Ancak bu sonu\u00e7lar dikkatli bir \u015fekilde yorumlanmal\u0131d\u0131r. COVD-19 a\u015f\u0131s\u0131n\u0131n geli\u015ftirilmesindeki zorluklar daha \u00f6nce benzeri g\u00f6r\u00fclmemi\u015f ve bu ba\u011f\u0131\u015f\u0131kl\u0131k tepkilerini tetikleme yetene\u011fi, a\u015f\u0131n\u0131n insanlar\u0131 COVID-19’dan koruyaca\u011f\u0131n\u0131 g\u00f6stermez. “<\/p>\n\n\n\n
Ara\u015ft\u0131rmac\u0131lar \u015fimdi, a\u015f\u0131ya d\u00fc\u015f\u00fck veya orta doz veya plasebo verilecek 500 kat\u0131l\u0131mc\u0131y\u0131 i\u00e7eren daha b\u00fcy\u00fck, faz 2 bir \u00e7al\u0131\u015fma ba\u015flatt\u0131lar. Bu \u00e7al\u0131\u015fma ayr\u0131ca 60 ya\u015f\u0131n \u00fczerindeki kat\u0131l\u0131mc\u0131lar\u0131 da i\u00e7erecek ve a\u015f\u0131lamadan sonra alt\u0131 aya kadar olan yan etkilere bakacakt\u0131r.<\/p>\n\n\n\n
Di\u011fer birka\u00e7 koronavir\u00fcs a\u015f\u0131s\u0131 aday\u0131 bu hafta umut verici geli\u015fmeler bildirdi.\u00a018 May\u0131s Pazartesi g\u00fcn\u00fc, biyoteknoloji \u015firketi Moderna, mRNA-1273 adl\u0131 a\u015f\u0131 aday\u0131n\u0131n dozlar\u0131n\u0131 alan 45 g\u00f6n\u00fcll\u00fcn\u00fcn 15 g\u00fcn i\u00e7inde antikor geli\u015ftirdi\u011fini ve kanlar\u0131nda g\u00f6r\u00fclen antikor seviyesinin insanlarda g\u00f6r\u00fclenlerle kar\u015f\u0131la\u015ft\u0131r\u0131labilir oldu\u011funu duyurdu. Daha \u00f6nce COVID-19’dan kurtulmu\u015f olan\u00a0Live Science rapor<\/u>\u00a0etmi\u015fti\u00a0.<\/p>\n\n\n\n
Buna ek olarak, Oxford \u00dcniversitesi’ndeki ara\u015ft\u0131rmac\u0131lar, ChAdOx1-nCov19 adl\u0131 a\u015f\u0131 adaylar\u0131n\u0131n \u015fimdi 10.000’den fazla ki\u015fiyi i\u00e7eren ileri klinik \u00e7al\u0131\u015fmalarda test edilece\u011fini ve dozlar\u0131n bu Eyl\u00fcl ay\u0131n\u0131n ba\u015flar\u0131nda\u00a0NBC News’e g\u00f6re kullan\u0131labilece\u011fini a\u00e7\u0131klad\u0131<\/u>\u00a0.<\/p>\n","protected":false},"excerpt":{"rendered":"
Yeni bir ara\u015ft\u0131rmaya g\u00f6re, \u00c7in’de geli\u015ftirilen\u00a0potansiyel bir\u00a0koronavir\u00fcs a\u015f\u0131s\u0131\u00a0, 100’den fazla ki\u015fide denemeden sonra g\u00fcvenli ve ba\u011f\u0131\u015f\u0131kl\u0131k sa\u011fland\u0131. Ad5-nCoV ad\u0131 verilen a\u015f\u0131, \u00c7inli CanSino Biologics \u015firketi taraf\u0131ndan geli\u015ftiriliyor ve Mart ay\u0131nda insan deneklerine giren ilk koronavir\u00fcs a\u015f\u0131lar\u0131ndan biriydi.\u00a0\u015eimdi, d\u00fcnya \u00e7ap\u0131nda geli\u015ftirilmekte olan 100’den fazla farkl\u0131 koronavir\u00fcs a\u015f\u0131s\u0131 vard\u0131r ve bunlar\u0131n en az sekiz tanesi insan denemeleri […]<\/p>\n","protected":false},"author":1,"featured_media":489,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,13],"tags":[113,198,199,220],"class_list":["post-488","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim","category-saglik","tag-asi-2","tag-corona","tag-corona-asisi","tag-deney"],"_links":{"self":[{"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/wp\/v2\/posts\/488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=488"}],"version-history":[{"count":0,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/wp\/v2\/posts\/488\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=\/"}],"wp:attachment":[{"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bilogtek.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}